Clinical and immunological analysis of the effectiveness of local application of vitamin D<sub>3</sub> in experimental colitis

The pathogenesis of inflammatory bowel diseases has not been fully studied, and the therapies used have side effects that limit their use. purpose this study is to conduct a clinical immunological analysis effectiveness vitamin D 3 in original rectal suppositories experimental colitis (EC). EC was modeled with oxazolone. Original group 5-ASA 4 were per rectum . clinic evaluated on Disease activity index scale. expression MPO TNFa, content neutrophils, lymphocytes, eosinophils, histiocytes, plasmocytes, fibroblasts, ulcerative defect, tissue damage determined focus colon injury. carried out days 2, 6. With EC, DAI increases for entire day, TNFa increase lesion, defect fixed, neutrophil-lymphocytic infiltration increases, TDI increases. When comparing morphometric parameters alteration zone under conditions use, contrast use 5-ASA, decrease number an fibroblasts revealed day plasmocytes 4, histiocytes diameter no significant differences between compared groups. , higher 6; 4. In using signs, size lesion are comparable 50 mg 5-ASA; more pronounced respect dynamics cellular composition colon.